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Silibinin induces cell cycle G0/G1-phase arrest in oral cancer cells. (A) YD10B and Ca9-22 cells were treated with silibinin (0, 50, 100, and 200 μM) for 48 h and stained with PI. Cell cycle distribution was analyzed using flow cytometry. (B) Bar graph representing the proportions of cells in different phases. (C) The protein expression levels of cyclin-dependent kinase (CDK) 4, CDK6, cyclin D1 and cyclin E1 determined using western blotting. *p<0.05; ** p< 0.01; *** p< 0.001.
