Table 1.

Dysfunctions of exosomal IncRNAs in NSCLC.

Exosomal lncRNAs	Sample	Origin	Expression	Function	References
MALAT1	Serum, culture medium	NSCLC cells	Increased	Promote proliferation, invasion and migration, and reduce apoptosis	23, 82
HOTAIR	Serum, culture medium	Lung cancer cells	Increased	Promote proliferation, invasion and migration	83, 84
LINC00662	Plasma	NSCLC cells	Increased	Promote proliferation, cell cycle arrest, invasion, and migration, and inhibit apoptosis	85
UFC1	Serum	NSCLC cells	Increased	Promote proliferation, cell cycle arrest, invasion, and migration, and inhibit apoptosis	86
FOXD3-AS1	Culture medium	NSCLC cells	Increased	Promote proliferation and invasion, and inhibit apoptosis caused by 5-FU	87
SCIRT	Malignant pleural effusions (MPEs), plasma, culture medium	NSCLC and SCLC cells	Increased	Promote invasion and migration	89
lnc-MMP2-2	Culture medium	TGF-β-mediated NSCLC cells	Increased	Promote invasion, migration and brain metastasis, and reduce permeability of vascular endothelial cells	91-96
SOX2-OT	Peripheral blood	NSCLC cells	Increased	Promote invasion, migration, bone metastasis and facilitate M2 macrophage polarization	97, 121
GAS5	Serum, culture medium	NSCLC cells	Decreased	Promote tumor angiogenesis	104-106
H19	Culture medium	NSCLC cells	Increased	Promote gefifitinib resistance	111
UCA1	Culture medium	Gefitinib-resistant NSCLC cells	Increased	Promote gefifitinib resistance	112
RP11-838N2.4	Serum, culture medium	Eelotinib-resistant NSCLC cells	Increased	Promote erlotinib resistance	113
MSTRG.292666.16	Plasma, culture medium	Osimertinib-resistant NSCLC cells	Increased	Promote osimertinib resistance	114
LINC00313	Culture medium	NSCLC cells	Increased	Promote M2 macrophage polarization	120
HOTAIRM1	Culture medium	NSCLC cells	Increased	Be associated with CAFs	122
lnc-MZT2A-5:1	Culture medium	Osimertinib-resistant NSCLC cells	Increased	Promote the migration and inflammation of fibroblasts	123