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. 2023 Jun 26;14(10):1920–1934. doi: 10.7150/jca.85032

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The expression of Cdc42 and PAK1 promotes the expression of p38MAPK and the phosphorylation level of STMN1, as well as the invasion and migration of CoCl₂-treated cells. Cdc42 directly regulates its interacting proteins cathepsin B and D to participate in the invasion and migration of CoCl₂-treated cells. Cdc42 can directly activate PAK1 and active PAK1 can phosphorylate STMN1 at sites of Ser16, Ser25, Ser38, and Ser63. Phosphorylated STMN1 can be localized in the nucleus, which further regulates the process of cytoskeleton remodeling, involved in asymmetric division of CoCl₂-treated cells and G2/M cell cycle arrest.