Table 2.
The p values of the paired t-test analysis for each pair of molecules among the top 20 molecules ranked by applying the random forest to all 181 molecules
SCF | MAD HOMOLOG 5 | PPY | FASLG | FGF-5 | CXCL1 | MMP-10 | XPNPEP2 | ESM-1 | PHOSPHORIC ACID | PD-L1 | EPHA2 | FLT3L | 4E-BP1 | TRAIL | MCP-1 | TLR3 | CD27 | FGF-BP1 | HK14 | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SCF | 0 | 0.6963 | 0.0017 | 0.0006 | 0.0004 | 0.0023 | 0.3286 | 0.361 | 0.0003 | 0.0859 | 0.0333 | 0.0073 | 0.0056 | 0.1307 | 0.1309 | 0.0148 | 0.0432 | 0.0116 | 0.1303 | 0.1215 |
MAD HOMOLOG 5 | 0.6963 | 0 | 0.0038 | 0.0014 | 0.0013 | 0.0153 | 0.6643 | 0.5633 | 0.0006 | 0.1622 | 0.146 | 0.0305 | 0.0442 | 0.2792 | 0.5298 | 0.0506 | 0.0586 | 0.0252 | 0.2913 | 0.2387 |
PPY | 0.0017 | 0.0038 | 0 | 0.9554 | 0.7183 | 0.4656 | 0.0033 | 0.0054 | 0.8852 | 0.0413 | 0.0721 | 0.1935 | 0.2713 | 0.0397 | 0.0096 | 0.1833 | 0.2008 | 0.2943 | 0.0166 | 0.0205 |
FASLG | 0.0006 | 0.0014 | 0.9554 | 0 | 0.6618 | 0.4225 | 0.0018 | 0.0015 | 0.9137 | 0.0376 | 0.0732 | 0.142 | 0.2782 | 0.0277 | 0.0039 | 0.166 | 0.1646 | 0.2553 | 0.0112 | 0.0051 |
FGF-5 | 0.0004 | 0.0013 | 0.7183 | 0.6618 | 0 | 0.3008 | 0.002 | 0.0018 | 0.6315 | 0.0209 | 0.0378 | 0.1085 | 0.1423 | 0.0145 | 0.0033 | 0.0857 | 0.0983 | 0.1787 | 0.01 | 0.0147 |
CXCL1 | 0.0023 | 0.0153 | 0.4656 | 0.4225 | 0.3008 | 0 | 0.0115 | 0.0376 | 0.5516 | 0.2144 | 0.2567 | 0.5558 | 0.6492 | 0.1072 | 0.0076 | 0.4841 | 0.5033 | 0.691 | 0.0583 | 0.0429 |
MMP-10 | 0.3286 | 0.6643 | 0.0033 | 0.0018 | 0.002 | 0.0115 | 0 | 0.9115 | 0.0073 | 0.3345 | 0.1225 | 0.0486 | 0.0419 | 0.5293 | 0.8731 | 0.0542 | 0.1309 | 0.0226 | 0.5308 | 0.4234 |
XPNPEP2 | 0.361 | 0.5633 | 0.0054 | 0.0015 | 0.0018 | 0.0376 | 0.9115 | 0 | 0.0125 | 0.3469 | 0.2814 | 0.1044 | 0.0921 | 0.5733 | 0.9708 | 0.1341 | 0.1636 | 0.0719 | 0.6209 | 0.519 |
ESM-1 | 0.0003 | 0.0006 | 0.8852 | 0.9137 | 0.6315 | 0.5516 | 0.0073 | 0.0125 | 0 | 0.0593 | 0.114 | 0.1401 | 0.3336 | 0.0335 | 0.0061 | 0.2512 | 0.2426 | 0.3007 | 0.013 | 0.0129 |
PHOSPHORIC ACID | 0.0859 | 0.1622 | 0.0413 | 0.0376 | 0.0209 | 0.2144 | 0.3345 | 0.3469 | 0.0593 | 0 | 0.829 | 0.4717 | 0.446 | 0.7561 | 0.422 | 0.517 | 0.5868 | 0.3887 | 0.6436 | 0.762 |
PD-L1 | 0.0333 | 0.146 | 0.0721 | 0.0732 | 0.0378 | 0.2567 | 0.1225 | 0.2814 | 0.114 | 0.829 | 0 | 0.5517 | 0.4038 | 0.5749 | 0.1934 | 0.5838 | 0.7439 | 0.415 | 0.5413 | 0.547 |
EPHA2 | 0.0073 | 0.0305 | 0.1935 | 0.142 | 0.1085 | 0.5558 | 0.0486 | 0.1044 | 0.1401 | 0.4717 | 0.5517 | 0 | 0.8913 | 0.3318 | 0.0648 | 0.9749 | 0.9147 | 0.7529 | 0.2438 | 0.2666 |
FLT3L | 0.0056 | 0.0442 | 0.2713 | 0.2782 | 0.1423 | 0.6492 | 0.0419 | 0.0921 | 0.3336 | 0.446 | 0.4038 | 0.8913 | 0 | 0.2581 | 0.0333 | 0.8507 | 0.8279 | 0.94 | 0.2181 | 0.2617 |
4E-BP1 | 0.1307 | 0.2792 | 0.0397 | 0.0277 | 0.0145 | 0.1072 | 0.5293 | 0.5733 | 0.0335 | 0.7561 | 0.5749 | 0.3318 | 0.2581 | 0 | 0.5541 | 0.1918 | 0.4236 | 0.2596 | 0.924 | 0.9861 |
TRAIL | 0.1309 | 0.5298 | 0.0096 | 0.0039 | 0.0033 | 0.0076 | 0.8731 | 0.9708 | 0.0061 | 0.422 | 0.1934 | 0.0648 | 0.0333 | 0.5541 | 0 | 0.066 | 0.1962 | 0.0647 | 0.6469 | 0.5674 |
MCP-1 | 0.0148 | 0.0506 | 0.1833 | 0.166 | 0.0857 | 0.4841 | 0.0542 | 0.1341 | 0.2512 | 0.517 | 0.5838 | 0.9749 | 0.8507 | 0.1918 | 0.066 | 0 | 0.9421 | 0.8181 | 0.2741 | 0.3109 |
TLR3 | 0.0432 | 0.0586 | 0.2008 | 0.1646 | 0.0983 | 0.5033 | 0.1309 | 0.1636 | 0.2426 | 0.5868 | 0.7439 | 0.9147 | 0.8279 | 0.4236 | 0.1962 | 0.9421 | 0 | 0.7566 | 0.3418 | 0.3587 |
CD27 | 0.0116 | 0.0252 | 0.2943 | 0.2553 | 0.1787 | 0.691 | 0.0226 | 0.0719 | 0.3007 | 0.3887 | 0.415 | 0.7529 | 0.94 | 0.2596 | 0.0647 | 0.8181 | 0.7566 | 0 | 0.1532 | 0.1312 |
FGF-BP1 | 0.1303 | 0.2913 | 0.0166 | 0.0112 | 0.01 | 0.0583 | 0.5308 | 0.6209 | 0.013 | 0.6436 | 0.5413 | 0.2438 | 0.2181 | 0.924 | 0.6469 | 0.2741 | 0.3418 | 0.1532 | 0 | 0.8822 |
HK14 | 0.1215 | 0.2387 | 0.0205 | 0.0051 | 0.0147 | 0.0429 | 0.4234 | 0.519 | 0.0129 | 0.762 | 0.547 | 0.2666 | 0.2617 | 0.9861 | 0.5674 | 0.3109 | 0.3587 | 0.1312 | 0.8822 | 0 |
The paired t test assesses the pairwise dependencies of the most discriminative 20 molecules. Pairs with p > 0.05 show strong dependency within that pair