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. Author manuscript; available in PMC: 2024 Apr 19.
Published in final edited form as: Cell Syst. 2023 Mar 30;14(4):273–284.e5. doi: 10.1016/j.cels.2023.03.001

Figure 5.

Figure 5.

SPAN-TCR Entropy Analysis of Putative SARS-CoV-2 TCRs. A. Contributions to entropy for 2-mers in YLNTLTLAV TCRs at each relative position of the α chain identify 2-mers essential to binding. B. A large entropy reduction is associated with 2-mer GE. C. The frequency and average entropy reduction of 2-mers are plotted (error bars = standard deviation) for all SARS-CoV-2 epitopes contained in MIRA. YE is notable as a 2-mer with high frequency and a strong entropy reducing influence. D. The frequency and entropy reduction of the YE 2-mer in different epitopes is plotted. Two epitope groups which contain YE at similar frequency but different entropy reduction are circled. The inset shows that YE only restricts the V gene usage for epitope group [SEHDY], while J gene usage and entropy are similar. E. Within CDR3s specific to a single epitope group, YE is the most essential. F. Plot showing that for CDR3s containing YE between positions 0.7–0.8, the CDR3 composition is restricted.