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. Author manuscript; available in PMC: 2024 Apr 19.
Published in final edited form as: Cell Syst. 2023 Mar 30;14(4):273–284.e5. doi: 10.1016/j.cels.2023.03.001

Figure 6.

Figure 6.

Epitope sequence and TCR entropy correlation. A. The TCR entropy reduction profile similarities between major epitopes (epitopes with >200 paired chains, n=17) in VDJdb are plotted. The entropy reduction profile similarity falls within a range for each epitope(136 comparisons). B. Entropy profile differences are plotted against the Levenshtein distance between epitope sequences. There is a significant correlation between Levenshtein distance between epitopes and TCR entropy profile differences. A triad of 3 epitopes, AVFDRKSDAK, KLGGALQAK, and RLRAEAQVK, has the smallest difference by entropy profile (linear regression). C. Entropy profiles for the most differential k-mers are shown for epitopes KLGGALQAK and AVFDRKSDAK together, and KLGGALQAK and DATYQRTRALVR (arbitrary units, linear scale). D. Entropy reduction analysis was performed using MIRA TCR β chains, showing the same trends (n=61, 1830 comparisons, linear regression). See also Fig. S6.