FIG. 5.

Sequence homologies between the N-terminal (A) and C-terminal (B) domains of Fcr1p and Pdr1p. The amino acid sequences of Fcr1p and Pdr1p were aligned with the BESTFIT program (20). Identical and conserved residues are shaded in black and grey, respectively, using the Boxshade program. The conserved cysteines in the C₆ zinc cluster motif are indicated by asterisks, and the leucine residues mutated in the gain-of-function pdr1-8 and PDR1-12 mutants (L1036W and L1039Q [12, 66]) are indicated by arrows.