Skip to main content
. 2023 Jul 19;19(7):e1011493. doi: 10.1371/journal.ppat.1011493

Fig 4. Effect of S100A9 deletion or reconstitution on lung antibacterial immunity in S. pneumoniae-infected bone-marrow chimeric mice.

Fig 4

(A) Endogenous S100A9 levels in BALF of chimeric mice on day 1 after pneumococcal challenge (n = 7–10 mice per group). (B,C) Bacterial loads in BAL fluids (B) and lung tissue (C) of S. pneumoniae-challenged chimeric mice on day 1 post-infection (n = 8–9 mice per group). (D) Zinc levels in lungs of S. pneumoniae-infected chimeric mice on day 1 post-infection, relative to controls (n = 8 mice per treatment group). Data are shown as means ± SD and are representative of two independently performed experiments. (E,F) Survival of chimeric mice infected with S. pneumoniae during an observation period of 10 days (n = 9–10 mice per group). The data represent two independent experiments. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001, ****p ≤ 0.0001 compared to chimeric controls, +p ≤ 0.05; ++p ≤ 0.01 compared to untreated controls (Kruskal-Wallis test, log-rank test).