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. Author manuscript; available in PMC: 2023 Jul 19.
Published in final edited form as: J Med Chem. 2019 Dec 10;62(24):11423–11429. doi: 10.1021/acs.jmedchem.9b01207

Table 1.

CREB Inhibitory Activity of Different Compounds

compd CREB inhibition (IC50, μM)a
666-15 0.081 ± 0.04
3 0.25 ± 0.11
11 26.3 ± 13.6
12 >50
a

The IC50 refers to the concentration needed to inhibit 50% of the CREB-mediated gene transcription in HEK 293T cells using a transcription Renilla luciferase reporter assay. The data are presented as mean ± SD of at least two independent experiments, which were performed in triplicate.