Table 1.
Acromegaly | Prolactinoma | NFPA | Total | p value | |
---|---|---|---|---|---|
N | 220 | 372 | 470 | 1062 | |
Male sex | 86 (39.1%)p | 96 (25.8%)a,n | 204 (43.4%)p | 386 (36.3%) | 0.001 |
Age (mean ± SD, years) | |||||
Actual age | 54.9 ± 13.5p | 41.1 ± 13.8a,n | 55.5 ± 16.5p | 50.6 ± 16.5 | 0.001 |
At diagnosis of PA | 47.2 ± 13.6p,n | 35.4 ± 13.0a,n | 51.2 ± 16.1a,p | 44.9 ± 16.2 | 0.001 |
Malignancy in the family | 96 (43.6%) | 192 (51.6%)n* | 207 (44.0%)p* | 495 (46.6%) | 0.056 |
1° relatives | 55 (25.0%) | 77 (20.7%)n | 140 (29.8%)p | 272 (25.6%) | 0.011 |
Parents | 41 (18.6%) | 66 (17.7.%)n* | 110 (23.4%)p* | 217 (20.4%) | 0.098 |
Siblings | 15 (6.8%)p | 11 (3.0%)a,n | 34 (7.2%)p | 60 (5.6%) | 0.020 |
2&3° relatives | 55 (25.0%)p | 144 (38.7%)a,n | 99 (21.1%)p | 298 (28.1%) | 0.001 |
All degrees relatives** | 14 (6.4%) | 29 (7.8%) | 32 (6.8%) | 75 (7.1%) | 0.673 |
Breast cancer in 1° rel | 4 (1.8%)n,p* | 19 (5.1%)a | 29 (6.2%)a* | 52 (4.9%) | 0.046 |
Lung cancer in 1° rel | 9 (4.1%) | 9 (2.4%) | 16 (3.4%) | 34 (3.2%) | 0.507 |
Colon cancer in 1° rel | 6 (2.7%) | 13 (3.5%) | 16 (3.4%) | 35 (3.3%) | 0.866 |
Breast cancer in 2&3° rel | 12 (5.5%)p | 41 (11.0%)a,n | 19 (4.0%)p | 72 (6.8%) | 0.001 |
Lung cancer in 2&3° rel | 14 (6.4%) | 37 (9.9%)n | 18 (3.8%)p | 69 (6.5%) | 0.002 |
Colon cancer in 2&3° rel | 5 (2.3%) | 21 (5.6%) | 25 (5.3%) | 51 (4.8%) | 0.140 |
PA pituitary adenoma, NFPA nonfunctioning pituitary adenoma, 1° first-degree relatives, 2&3° second- and third-degree relatives, rel relatives
Single group by group comparisons, with correction (p < 0.05): aAcromegaly, pProlactinoma, nNFPA; *Single group by group comparisons, without correction (p < 0.05)
**Some patients are represented in more than one category if having both a first-degree and second- and third-degree relative with a cancer