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. 2018 Sep 8;10(1):45–50. doi: 10.1007/s12672-018-0348-3

Table 1.

Clinical characteristics and history of malignancy in patients with pituitary adenoma and their families

Acromegaly Prolactinoma NFPA Total p value
N 220 372 470 1062
Male sex 86 (39.1%)p 96 (25.8%)a,n 204 (43.4%)p 386 (36.3%) 0.001
Age (mean ± SD, years)
 Actual age 54.9 ± 13.5p 41.1 ± 13.8a,n 55.5 ± 16.5p 50.6 ± 16.5 0.001
 At diagnosis of PA 47.2 ± 13.6p,n 35.4 ± 13.0a,n 51.2 ± 16.1a,p 44.9 ± 16.2 0.001
Malignancy in the family 96 (43.6%) 192 (51.6%)n* 207 (44.0%)p* 495 (46.6%) 0.056
 1° relatives 55 (25.0%) 77 (20.7%)n 140 (29.8%)p 272 (25.6%) 0.011
 Parents 41 (18.6%) 66 (17.7.%)n* 110 (23.4%)p* 217 (20.4%) 0.098
 Siblings 15 (6.8%)p 11 (3.0%)a,n 34 (7.2%)p 60 (5.6%) 0.020
 2&3° relatives 55 (25.0%)p 144 (38.7%)a,n 99 (21.1%)p 298 (28.1%) 0.001
 All degrees relatives** 14 (6.4%) 29 (7.8%) 32 (6.8%) 75 (7.1%) 0.673
Breast cancer in 1° rel 4 (1.8%)n,p* 19 (5.1%)a 29 (6.2%)a* 52 (4.9%) 0.046
Lung cancer in 1° rel 9 (4.1%) 9 (2.4%) 16 (3.4%) 34 (3.2%) 0.507
Colon cancer in 1° rel 6 (2.7%) 13 (3.5%) 16 (3.4%) 35 (3.3%) 0.866
Breast cancer in 2&3° rel 12 (5.5%)p 41 (11.0%)a,n 19 (4.0%)p 72 (6.8%) 0.001
Lung cancer in 2&3° rel 14 (6.4%) 37 (9.9%)n 18 (3.8%)p 69 (6.5%) 0.002
Colon cancer in 2&3° rel 5 (2.3%) 21 (5.6%) 25 (5.3%) 51 (4.8%) 0.140

PA pituitary adenoma, NFPA nonfunctioning pituitary adenoma, first-degree relatives, 2&3° second- and third-degree relatives, rel relatives

Single group by group comparisons, with correction (p < 0.05): aAcromegaly, pProlactinoma, nNFPA; *Single group by group comparisons, without correction (p < 0.05)

**Some patients are represented in more than one category if having both a first-degree and second- and third-degree relative with a cancer