Table 4.
Clinical characteristics and history of malignancy in patients with pituitary adenoma diagnosed prior 25 years of age and after 26 years of age
| PA diagnosed prior 25 years of age | PA diagnosed after 26 years of age | p value | |
|---|---|---|---|
| N | 147 (13.8%) | 915 (86.2%) | |
| Male sex | 31 (21.1%) | 355 (38.8%) | < 0.001a |
| Age (yrs.) | |||
| Actual age | 27.3 ± 8.4 | 54..4 ± 14.2 | < 0.001b |
| At diagnosis of PA | 21.3 ± 3.0 | 48.7 ± 14.1 | < 0.001b |
| Type of PA | |||
| Acromegaly | 14 (9.5%) | 206 (22.5%) | < 0.001a |
| Prolactinoma | 96 (65.3%) | 276 (30.2%) | |
| NFPA | 37 (25.2%) | 433 (47.3%) | |
| Hypopituitarism | 15 (10.2%) | 253 (27.7%) | < 0.001a |
| Positive family history of Mg | 74 (50.3%) | 421 (46.0%) | 0.329 a |
| 1° relatives | 16 (10.9%) | 256 (28.0%) | < 0.001a |
| 2&3° relatives | 62 (42.2%) | 236 (25.8%) | < 0.001a |
| Breast cancer in 1° rel | 8 (5.4%) | 44 (4.8%) | 0.741a |
| Breast cancer in 2&3° rel | 16 (10.9%) | 56 (6.1%) | 0.033 a |
| Lung cancer in 1° rel | 1 (0.7%) | 33 (3.6%) | 0.074c |
| Lung cancer in 2&3° rel | 16 (10.9%) | 53 (5.8%) | 0.020 a |
| Colon cancer in 1° rel | 1 (0.7%) | 12 (1.3%) | 0.076 c |
| Colon cancer in 2&3° rel | 14 (9.5%) | 37 (4.0%) | 0.004 a |
*Results are presented as counts (%). or mean ± standard deviation
PA pituitary adenoma, Mg malignancy, NFPA nonfunctioning pituitary adenoma, 1° first-degree relatives, 2&3° second- and third-degree relatives
aPearson chi-square test
bt test
cFisher’s exact test