Table 3.
Effect of cisplatin on the apoptotic rate in IGF1R downregulated Cal27-regIGF1R and SCC25-regIGF1R cells
| Cal27-regIGF1R | SCC25-regIGF1R | |||||
|---|---|---|---|---|---|---|
| Cell treatment | Apoptosis M ± SEM | p value | Apoptosis M ± SEM | p value | ||
| Early | Late | Early | Late | |||
| −dox | 1.2 ± 0.3 | 3.7 ± 0.4 | > 0.05 | 1.2 ± 0.2 | 1.8 ± 0.1 | > 0.05 |
| +dox | 1.1 ± 0.3 | 3.6 ± 0.5 | 2.6 ± 0.3 | 2.9 ± 0.3 | ||
| Cisp5 | 2.7 ± 0.3 | 5.5 ± 0.4 | < 0.05 | 3.7 ± 0.3 | 8.4 ± 0.8 | < 0.05 |
| Cisp5 + dox | 5.8 ± 0.7 | 8.2 ± 0.8 | 9.7 ± 0.7 | 15.6 ± 1.1 | ||
| Cisp10 | 7.1 ± 0.5 | 11.5 ± 1.7 | < 0.05 | 11.7 ± 0.9 | 21.0 ± 1.8 | < 0.05 |
| Cisp10 + dox | 15.0 ± 0.9 | 25.1 ± 0.8 | 23.4 ± 1.4 | 27.1 ± 0.9 | ||
| Cisp 25 | 16.0 ± 0.9 | 25.5 ± 1.6 | < 0.05 | 23.9 ± 1.3 | 27.2 ± 1.4 | < 0.05 |
| Cisp25 + dox | 19.5 ± 1.3 | 27.9 ± 0.8 | 26.5 ± 0.6 | 30.6 ± 2.0 | ||