Table 2.
Final multivariable models of Grade 3+ INH-related toxicity in the prior 3 months.
| Model 1 Baseline alcohol use by self-report/PEth combineda (N = 298) |
Model 2 Baseline alcohol use by self-report aloneb (N = 298) |
Model 3 Time-updated alcohol use by self-report/PEtha (N = 297) |
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| aOR (95% CI) | P | aOR (95% CI) | P | aOR (95% CI) | P | |
| Alcohol use | 0.32 | 0.14 | 0.04 | |||
| None | 1.00 | 1.00 | 1.00 | |||
| Low | 0.43 (0.13–1.44) | 0.38 (0.13–1.10) | 0.10 (0.01–0.76) | |||
| Medium | 0.36 (0.10–1.29) | 0.30 (0.09–1.08) | 0.23 (0.06–0.93) | |||
| High/very high | 0.56 (0.16–1.93) | 0.50 (0.12–2.04) | 0.73 (0.23–2.26) | |||
| Age | 0.98 (0.93–1.03) | 0.47 | 0.98 (0.93–1.03) | 0.43 | 0.96 (0.91–1.01) | 0.15 |
| Sex | 0.83 | 0.69 | 0.58 | |||
| Female | 1.00 | 1.00 | 1.00 | |||
| Male | 1.11 (0.41–3.05) | 1.21 (0.47–3.16) | 1.32 (0.49–3.57) | |||
| Health status | 0.39 | 0.41 | 0.24 | |||
| Good/fair/poor | 1.00 | 1.00 | 1.00 | |||
| Excellent/very good | 0.70 (0.31–1.59) | 0.70 (0.31–1.61) | 0.60 (0.26–1.40) | |||
| Study visit | 0.02 | 0.02 | 0.04 | |||
| 3 months | 1.00 | 1.00 | 1.00 | |||
| 6 months | 0.33 (0.13–0.86) | 0.33 (0.13–0.86) | 0.37 (0.15–0.94) | |||
| INH adherence, prior 3 months | 0.08 | |||||
| < 90% | – | – | 1.00 | |||
| ≥ 90% | – | – | 2.79 (0.90–8.61) | |||
a
Self-report/PEth combined categories assigns the higher of the self-report and PEth categories. Self-report as below. PEth categories: None: PEth <8 ng/ml; Low: PEth 8–<50 ng/ml; Medium: PEth 50–200 ng/ml, High: PEth ≥200 ng/ml.
b
Self-report categories: None: AUDIT-C = 0; Low: AUDIT-C 1--2 for women and 1–3 for men; Medium: AUDIT-C 3–5 for women and 4--5 for men; High/very high: AUDIT-C ≥6.