Table 3.
Final multivariable models of Grade 2 INH-related toxicity in the prior 3 months (n = 273 participants with no Grade 3+ INH-related toxicities).
| Model 4 Baseline alcohol use by self-report and PEth combineda |
Model 5 Baseline alcohol use by self-report aloneb |
Model 6 Time-updated alcohol use by self-report and PEth combineda |
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| aOR (95% CI) | P | aOR (95% CI) | P | aOR (95% CI) | P | |
| Alcohol use | <0.01 | 0.07 | <0.01 | |||
| None | 1.00 | 1.00 | 1.00 | |||
| Low | 1.11 (0.44–2.76) | 1.00 (0.45–2.21) | 1.98 (0.84–4.65) | |||
| Medium | 0.69 (0.25–1.91) | 1.44 (0.60–3.44) | 0.97 (0.36–2.66) | |||
| High/very high | 3.63 (1.48–8.93) | 2.70 (1.12–6.49) | 3.58 (1.51–8.53) | |||
| Age | 0.98 (0.95–1.01) | 0.14 | 0.98 (0.95–1.01) | 0.17 | 0.97 (0.95–1.00) | 0.09 |
| Sex | 0.17 | 0.07 | 0.07 | |||
| Female | 1.00 | 1.00 | 1.00 | |||
| Male | 1.63 (0.81–3.25) | 1.83 (0.96–3.51) | 1.88 (0.96–3.70) | |||
| Health status | <0.01 | 0.07 | 0.03 | |||
| Good/fair/poor | 1.00 | 1.00 | 1.00 | |||
| Excellent/very good | 0.43 (0.23–0.79) | 0.59 (0.33–1.04) | 0.50 (0.27–0.92) | |||
| Study visit | <0.01 | <0.01 | <0.01 | |||
| 3 months | 1.00 | 1.00 | 1.00 | |||
| 6 months | 0.37 (0.20–0.68) | 0.38 (0.21–0.68) | 0.38 (0.21–0.70) | |||
| ART adherence | 0.04 | 0.07 | 0.07 | |||
| Good/fair/poor/very poor | 1.00 | 1.00 | 1.00 | |||
| Excellent/very good | 3.13 (1.06–9.25) | 2.74 (0.93–8.12) | 2.76 (0.94–8.13) | |||
a
Self-report/PEth combined categories assigns the higher of the self-report and PEth categories. Self-report as below. PEth categories: None: PEth <8 ng/ml; Low: PEth 8–<50 ng/ml; Medium: PEth 50–200 ng/ml, High: PEth ≥200 ng/ml.
b
Self-report categories: None: AUDIT-C = 0; Low: AUDIT-C 1–2 for women and 1–3 for men; Medium: AUDIT-C 3–5 for women and 4–5 for men; High/very high: AUDIT-C ≥6.