Fig. 1.

Peak levels of Fc-mediated effector function are increased following an additional boost to the RV144 vaccine regiment.

ADCP (a), ADNP (b), ADCD (c), trogocytosis (d), and ADCC (e) were measured at weeks 0, 26, 50, and 72 in RV306 study participants. Black, red, and blue represent groups 1, 2, and 3 respectively. For ADNP and trogocystosis, N = 21, 25, and 25 for groups 1, 2, and 3 respectively. For ADCP, N = 21, 25, and 23 for groups 1, 2, and 3, respectively. For ADCD, N = 21, 17, and 23 for groups 1, 2, and 3, respectively. For ADCC, N = 9, 18, and 18 for groups 1, 2, and 3, respectively. The percentage of positive responses at each time point for each group is indicated at the top of each graph. Dotted lines indicate the cutoff for positivity. Error bars represent the median and interquartile range, respectively. ADCD, antibody-dependent complement deposition; ADCP, antibody-dependent cellular phagocytosis; ADNP, antibody-dependent neutrophil phagocytosis. ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001.