TABLE 2.
An overview of studies on exercise’s effects on mitochondrial biogenesis.
| Author year | Subjects | Exercise forms | Exercise duration | Exercise intensity | Protein level | Change |
|---|---|---|---|---|---|---|
| Kitaoka 2015 Beyfuss et al. (2018) | rat | Resistance exercise | 4 weeks, 3 day/week | no change | ||
| Mesquita 2020 Kitaoka et al. (2015) | older adults | resistance training | 10 weeks, 2 day/week | PGC-1α, TFAM,NRF1 | no change | |
| Koltai 2012 Mesquita et al. (2020) | rat | treadmill running | 6 weeks, 7 days/week | 60% Vo2max | PGC1α,SIRT1,TFAM,NRF1 | Increase |
| Kang 2013 Koltai et al. (2012) | rat | treadmill running | 12 weeks, 5 day/week | Moderate strength | PGC-1α, SIRT1,AMPK | Increase |
| Moore 2019 Kang et al. (2013) | mice | treadmill running | 90 mint | Moderate strength | PGC-1α, TFAM,NRF-1 | Increase |
| Gao 2021 Moore et al. (2019) | rats | treadmill running | 8 months | Moderate strength | AMPK, PGC-1α | Increase |
| Han 2022 Gao et al. (2021) | rats | treadmill running | 8 months, 5 days/week | MICT:75%–80% O2max HIIT: 45%–55% + 85–95% O2max | SIRT3, PGC-1α | Increase |
| Pirani 2023 Han et al. (2022) | old rats | treadmill running | 12 weeks HIIT:16-18 min MICT:30-60 mim | MICT: 65%–70% VO2max HIIT:85%–90% + 45%-75%VO2max | AMPK, PGC-1α,ERR | Increase |
| Heather 2018 (Johnson et al., 2021) | rats | Acute contractile activity | NRF-2, PGC-1α | Increase | ||
| Edgett 2013 Pirani et al. (2023) | adults | cycle ergometer | 3 h | the peak work rate of 100% or 73% or 133% | PGC-1α | Increase |
| Granata 2016 Edgett et al. (2013) | adults | cycle | 4 weeks, 3 days/week | 200% or 90% or 65% of peak power output | PGC-1α, p53 | Increase |
| Granata 2020 Granata et al. (2016) | adults | electronically braked cycle ergometer | 20 days, 2 times/day | HVT | PGC-1α, p53 | Increase |