Table 3.
Association with all-cause mortality in the OA and non-OA groups
| Group | Total, n | Deaths, n | Mortality rate per 1000 person–years (95% CI) | Unadjusted HR (95% CI) | Adjusted HR (95% CI)a |
|---|---|---|---|---|---|
| Non-OA control | 221 807 | 13 087 | 7.14 (7.02 to 7.27) | Reference | Reference |
|
| |||||
| OA (any site) | 221 807 | 20 617 | 13.52 (13.34 to 13.70) | 2.02 (1.98 to 2.06)b | 1.89 (1.85 to 1.93)b |
|
| |||||
| Site of OA | |||||
| Non-knee controls | 59 351 | 3637 | 7.94 (7.68 to 8.20) | Reference | Reference |
| Knee | 53 982 | 5038 | 14.70 (14.30 to 15.11) | 1.98 (1.90 to 2.06)b | 2.09 (2.01 to 2.19)b |
| Non-hip controls | 27 521 | 1783 | 8.38 (8.00 to 8.78) | Reference | Reference |
| Hip | 24 701 | 2503 | 15.90 (15.29 to 16.54) | 2.03 (1.91 to 2.16)b | 2.08 (1.95 to 2.21)b |
| Non-ankle/foot controls | 5874 | 252 | 5.34 (4.72 to 6.04) | Reference | Reference |
| Ankle/foot | 5231 | 355 | 9.89 (8.91 to 10.98) | 1.95 (1.66 to 2.28)b | 2.00 (1.70 to 2.36)b |
| Non-wrist/hand controls | 9570 | 361 | 4.99 (4.50 to 5.53) | Reference | Reference |
| Wrist/hand | 9729 | 605 | 9.68 (8.94 to 10.48) | 2.03 (1.79 to 2.32)b | 1.80 (1.58 to 2.06)b |
| Non-unspecified controls | 161 568 | 10 055 | 7.43 (7.28 to 7.57) | Reference | Reference |
| Unspecified | 155 540 | 14 981 | 14.27 (14.05 to 14.50) | 2.05 (2.00 to 2.10)b | 1.80 (1.75 to 1.84)b |
a
Adjusted for age, sex, smoking, alcohol, BMI, ECI, and number of comorbidities at baseline.
b
P<0.05. BMI = body mass index. ECI = Elixhauser Comorbidity Index. HR = hazard ratio. OA = osteoarthritis.