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. 2023 Jul 19;9(29):eadh9002. doi: 10.1126/sciadv.adh9002

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Fig. 3. — (A) Structure of dimer state-3 showing symmetric TIR arrangement in the cartoon with additional TIR density forming an inactive TIR assembly. (B) Representation of the 180° rotation of a TIR domain in the MapSPARTA dimer upon tetramerization. (C) Cartoon and surface representation show complete catalytic site formation (in red) upon TIR rotation.