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. 2023 Jul 19;9(29):eadg2697. doi: 10.1126/sciadv.adg2697

Fig. 7. DL@NP-M-M2pep achieves antitumor effects by polarizing TAMs from M2 to M1 in Hepa1-6-luc–derived orthotopic HCC mice.

Fig. 7.

(A) Tumor inoculation and treatment scheme. (B) The representative images of animals with different treatments. (C) The HCC development over a 21-day period (n = 6). (D) Animal survival (n = 10). (E) The M2 and M1 TAMs were detected using immunofluorescent staining assay (scale bars, 100 μm; n = 4). (F) Flow cytometric analysis of M2 and M1 TAMs (fig. S8) (n = 4) (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns to PBS).