Skip to main content
. 2023 Jul 19;9(29):eadg2697. doi: 10.1126/sciadv.adg2697

Fig. 8. DL@NP-M-M2pep remodels the immunosuppressive TME in Hepa1-6-luc–derived orthotopic HCC.

Fig. 8.

(A) The immunosuppressive cells such as MDSCs and Tregs in tumors (fig. S9). The immunostimulatory cells as NK cells, activated DCs, and effector T cells in tumors (figs. S10 to S13) (n = 4). (B) The expression of immunosuppressive cytokines (IL-10, TGF-β, and IL-4) in tumors was measured using enzyme-linked immunosorbent assay (ELISA) (n = 4). (C) The expression of immunostimulatory cytokines (IFN-γ, TNF-α, and IL-12) in tumors was measured using ELISA (n = 4). (D) The average number of apoptotic cells per high-power field was detected by terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick end labeling (TUNEL) and analyzed by ImageJ. (scale bar, 50 μm; n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns to PBS).