Table 2.
Clinicopathological features of thyroid cancer, mRNA expression for GHRH and GHRHR, and immunohistochemical staining for GHRHR
| Clinicopathological features | mRNA expression GHRH | mRNA expression GHRHR | Protein expression GHRHR | |||
|---|---|---|---|---|---|---|
| Not detectable | Positive | Not detectable | Positive | Negative | Positive | |
| Number of cases (n) | 18 | 14 | 17 | 14 | 10 | 31 |
| Age at diagnosis (n (%)) | ||||||
| ≤ 45 | 14 (46.7) | 7 (23.3) | 11 (37.9) | 10 (34.5) | 7 (17.5) | 18 (45.0) |
| > 45 | 3 (10.0) | 6 (20.0) | 4 (13.8) | 4 (13.8) | 3 (7.5) | 12 (30.0) |
| Gender (n (%)) | ||||||
| Female | 12 (40.0) | 12 (40.0) | 13 (44.8) | 11 (37.9) | 8 (20.0) | 26 (65.0) |
| Male | 5 (16.7) | 1 (3.3) | 2 (6.9) | 3 (10.4) | 2 (5.0) | 4 (10.0) |
| Tumor size (n (%)) | ||||||
| ≤ 2 cm | 7 (24.1) | 6 (20.7) | 6 (21.4) | 7 (25.0) | 1 (2.5) | 14 (35.9) |
| > 2 cm | 8 (27.6) | 8 (27.6) | 10 (35.7) | 5 (17.9) | 9 (23.1) | 15 (38.5) |
| Number of tumors (n (%)) | ||||||
| Single | 6 (24.0) | 7 (28.0) | 5 (20.0) | 8 (32.0) | 3 (8.1) | 19 (51.4) |
| Multiple | 6 (24.0) | 6 (24.0) | 9 (36.0) | 3 (12.0) | 5 (13.5) | 10 (27.0) |
| Vascular invasion (n (%)) | ||||||
| Absent | 2 (9.1) | 8 (36.4) | 8 (30.8) | 6 (23.1) | 3 (8.6) | 13 (37.1) |
| Present | 9 (40.9) | 3 (13.6) | 7 (26.9) | 5 (19.2) | 5 (14.3) | 14 (40.0) |
| Lymph node metastasis (n (%)) | ||||||
| Absent | 2 (12.5) | 5 (31.3) | 3 (20.0) | 4 (26.7) | 0 (0.0) | 12 (48.0) |
| Present | 8 (50.0) | 1 (6.2) | 6 (40.0) | 2 (13.3) | 5 (20.0) | 8 (32.0) |
| Extrathyroidal invasion (n (%)) | ||||||
| Absent | 8 (26.7) | 9 (30.0) | 9 (32.1) | 8 (28.6) | 7 (21.2) | 16 (48.5) |
| Present | 9 (30.0) | 4 (13.3) | 7 (25.0) | 4 (14.3) | 3 (9.1) | 7 (21.2) |
| Lymphocytic infiltrate (n (%)) | ||||||
| Absent | 9 (30.1) | 7 (23.3) | 9 (30.1) | 7 (23.3) | 7 (17.5) | 12 (30.0) |
| Present | 7 (23.3) | 7 (23.3) | 7 (23.3) | 7 (23.3) | 2 (5.0) | 19 (47.5) |
| MAPK alterations (n (%)) | ||||||
| Absent | 6 (18.7) | 8 (25.0) | 6 (19.4) | 8 (25.8) | 4 (10.0) | 9 (22.5) |
| Present | 12 (37.6) | 6 (18.7) | 11 (35.4) | 6 (19.4) | 5 (12.5) | 22 (55.0) |
Legend: The number of cases varies along features, according to the number of patients with the clinical information available