. 2018 Feb 20;9(3):144–155. doi: 10.1007/s12672-018-0327-8

Table 3.

Leptin and brain tumors: mechanistic observations

Tumor/Cell type	Investigated factor	Mechanism	Outcome	Ref.
Cultured GH-secreting human pituitary adenoma cells	Leptin priming	Spontaneous GH discharge reduced	Low GH levels in obesity	[90]
Cultured GH-secreting human pituitary adenoma cells	Leptin priming	GHRH-induced discharge increased	Low GHRH-induced GH in obesity	[90]
Glioblastoma cells	OB-Rb expression	STAT3, SOX2/OCT signaling axis	Invasiveness and proliferation ↓ temozolide resistance	[93]
Glioblastoma tumors	Resection and recurrence	Percentage of OB-Rb+ cells increased	Increased malignancy and self-renewal	[93]
OB-Rb+ tumors in nude mice	Leptin treatment	(Not specified)	Increased tumor volume	[93]
Glioma stem-like cells (CD133+)	Leptin treatment	JAK/STAT3 signaling pathway ↓ Increased MMP9, β-integrin, N-cadherin, and vimentin expression	Increased invasive ability	[94]