Table 2.
Gene expression differences between normal-weight, overweight, and obese women in premenopausal and postmenopausal states. *P < 0.05 stands for significance of ANOVA prior to post hoc testing
| Gene symbol | Gene name | P values from ANOVA | |
|---|---|---|---|
| Premenopause n = 57 | Postmenopause n = 55 | ||
| Estrogen synthase, receptor and responsive genes | |||
| CYP19A1 | Cytochrome P450, family 19, subfamily A, polypeptide 1 | 0.511 | 0.585 |
| ESR1 | Estrogen receptor 1 | 0.071 | 0.357 |
| CCND1 | Cyclin D1 | 0.879 | 0.001* |
| SUSD3 | Sushi domain containing 3 | 0.331 | 0.335 |
| PLIN2 | Perilipin 2 | 0.324 | 0.077 |
| Genes associated with the AMPK pathway | |||
| STK11 | Serine/threonine kinase 11 | 0.556 | 0.793 |
| PRKAA1 | Protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.194 | 0.845 |
| PRKAA2 | Protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.274 | 0.646 |
| MTOR | Mechanistic target of rapamycin (serine/threonine kinase) | 0.482 | 0.127 |
| RPS6KB1 | Ribosomal protein S6 kinase, 70 kDa, polypeptide 1 | 0.037* | 0.773 |
| EEF2 | Eukaryotic translation elongation factor 2 | 0.293 | 0.031* |
| ACACA | Acetyl-CoA carboxylase alpha | 0.896 | 0.585 |
| PFKFB2 | 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 0.944 | 0.985 |
| CRTC2 | CREB-regulated transcription coactivator 2 | 0.292 | 0.247 |
| CREB1 | cAMP-responsive element-binding protein 1 | 0.967 | 0.863 |
| Genes associated with the inflammation | |||
| TNF | Tumor necrosis factor | 0.590 | 0.668 |
| TNFRSF1A | Tumor necrosis factor receptor superfamily, member 1A | 0.390 | 0.845 |
| TNFRSF1B | Tumor necrosis factor receptor superfamily, member 1B | 0.567 | 0.949 |
| PTGS2 | Cytochrome c oxidase subunit II | 0.565 | 0.041* |
| JUNB | Jun B proto-oncogene | 0.770 | 0.641 |
| CEBPB | CCAAT/enhancer-binding protein (C/EBP), beta | 0.419 | 0.588 |
*P < 0.05 for comparison between normal-weight, overweight, and obese women