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Summary of phenotypical changes in a mouse model of thyroid cancer
| Animal model | Intervention | Phenotype | Reference |
|---|---|---|---|
| Thrb PV/PV Pten +/− | HFD-induced obesity | Large tumor size, shorter survival, more anaplastic change | 22 |
| Thrb PV/PV Pten +/− | STAT3 inhibitor, S3I-201 | Delay tumor growth and survival, inhibit lung metastasis | 42 |
| Thrb PV/PV Pten +/− | Metformin | Reduce capsular invasion, vascular invasion, and anaplasia | 61 |
