Table 1.
Clinical features of patients with bronchial carcinoid (BC) tumors in patients with multiple endocrine neoplasia type 1 (MEN1)
| Case | Age at diagnosis of MEN1 (years) | Age at diagnosis of BC tumor (years) | Sex | Diagnosis | Therapy | Lymph nodes and surgical margins report and number positive for metastatic BC tumor | Recurrence | Follow-up (years) | Death during follow-up (cause) | Tumor size, location, and pathology findings |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 39 | 39 | F | Reflux symptoms, followed by chest CT scan | Mediastinoscopy and wedge resection | 1/5 positive peribronchial lymph node | No | 10 | No | Right lower lobe, size not known, grade 1 neuroendocrine carcinoma |
| 2 | 38 | 40 | F | Screening chest x-ray | Mediastinoscopy and wedge resection | 0/14 lymph nodes | No | 13 | No | Left lower lobe 1 cm, BC tumor IA |
| 3 | 53 | 69 | M | Screening chest CT scan | Wedge resection | Lymph nodes not evaluated | No | 11 | Yes (unrelated cause) | Left upper lobe, size not known, BC tumor IA. |
| 4 | 25 | 34 | M | Screening chest x-ray | Lobectomy with mediastinal lymphadenectomy | 0/13 lymph nodes | No | 12 | No | Right middle lobe, 2.1 × 1.5 × 1.5 cm BC tumor |
| 5 | 24 | 42 | M | Screening chest CT scan | Wedge resection | Negative margins, no lymph nodes examined | No | 7 | No | Two right BC tumors, right lower lobe 1.5 × 1.4 cm and right middle lobe 0.6 × 0.5 cm |
| 6 | 25 | 37 | F | Screening chest CT scan | Mediastinoscopy and wedge resection | Negative margins, 0/2 lymph nodes | Residual symptomatic pulmonary nodules; required second lobectomy | 2 | No | First surgery typical BC tumor left lower lobe 1.1 × 1.4 cm; second surgery atypical BC right middle lobe 0.8 × 0.5 × 0.5 cm and right upper lobe 1.5 × 1.4 × 1.4 cm |
| 7 | 41 | 42 | M | Screening with chest x-ray | Mediastinoscopy and lobectomy | Negative margins; 0/14 lymph nodes | No | 9 | Yes (unknown) | Left lower lobe 2.7 × 2.5 × 2.5 cm BC tumor |
| 8 | 54 | 56 | F | Screening with chest x-ray | Lobectomy with mediastinal lymphadenectomy | Negative margins, 0/17 lymph nodes | Yes, 10 years postoperatively, subcentimeter nodule, no symptoms | 12 | Yes (unknown) | Left upper lobe 2.5 × 1.5 cm BC tumor |
| 9 | 50 | 40 | M | Screening with chest x-ray | Wedge resection | Negative margins | Yes, 2 years postoperatively, new nodule same area, required resection | 18 | No | Initial surgery right lower lobe 2 cm BC tumor; second surgery right lower lobe 1.5 cm BC tumor |
| 10 | 42 | 42 | F | Cough followed by chest CT scan | Wedge resection with mediastinal lymphadenectomy | Negative margins, 0/2 lymph nodes | Yes, asymptomatic subcentimeter nodules | 10 | No | Right lower lobe 1.6 × 1.5 × 2.5 cm BC tumor |
| 11 | 40 | 40 | M | Shortness of breath followed by chest x-ray | Lobectomy | Negative margins | Yes, 1 year postoperatively, asymptomatic subcentimeter nodules | 5 | No | Two BC tumors, right middle lobe 1.2 cm and right lower lobe 2.8 × 2.5 × 1.4 cm |
| 12 | 53 | 53 | M | Screening with chest CT scan | Mediastinoscopy | Negative margins, 0/9 lymph nodes | No | 1 | No | Right upper lobe 1.3 × 0.7 × 0.5 cm atypical BC tumor |
| 13 | 52 | 53 | M | Screening with chest CT scan | Mediastinoscopy and segmentectomy | Negative margins, 1/8 lymph nodes | No | 0.5 | No | Left lower lobe 0.9 × 0.8 × 0.7 cm grade 1 BC tumor |
F female, M male