Table 5.
Summary of selected MEN1 series with thymic carcinoid (TC) tumors
Author | Type of study | Location | Number of MEN1 cases | TC tumors | Prevalence (%) | Male (%) | Outcome |
---|---|---|---|---|---|---|---|
de Laat et al. 2014 | Observational study using a national database | Netherlands | 323 | 11 | 3.4 | 91 | 7 deceased by the end of follow-up (10-year survival of 25 %) |
Ferolla et al. 2005 | Observational study using a national registry | Italy | 221 | 7 | 3.2 | 100 | 3 died during follow-up (range, 23–120 months) |
Gibril et al. 2003 | Prospective observational, single referral center | US | 85 | 7 | 8.2 | 100 | 1 died during follow-up (range, 0.13–15.3 years) |
Goudet et al. 2009 | Observational study using national registry | France | 761 | 21 | 2.8 | 95.2 | 10 died during follow-up (10-year probability of survival 36.1 %) |
Sakurai et al. 2013 | Observational study using a registry | Japan | 560 | 28 | 5.0 | 64.3 | 8 died during follow-up (median follow-up of 6.7 years; 10-year probability of survival of 30.3 %) |
Teh et al. 1997 | Observational, different referral centers | Australia/Malaysia | 204 | 10 | 4.9 % | 100 | 9 patients died during follow-up (mean follow-up of 4.5 years) |
Teh et al. 1998 | Observational, different referral centers | Australia/Malaysia | Not clear | 10 | Not clear | 100 | 1 patient died during follow-up (range, 2–162 months) |
Present study | Observational, single referral center | US | 348 | 7 | 2.0 | 100 | 4 patients died during follow-up (range, 3–11 years) |