Table 3.
Summary of studies that reported associations between TERT promoter mutations and clinical and histopathological features, BRAF V600E mutation, and outcome of different types of thyroid cancer
| Study | Total no. of tumors | Age | Size | ETE | Vascular invasion | LNM | Distant mets | TNM stage | Recurrence | BRAF | Death |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Shi et al. [28] | 106 ATC | Yes | No | No | No | Yes | Yes | ||||
| Gandolfi et al. [29] | 121 | Yes | No | No | Yes | Yes | Yes | No | |||
| Muzza et al. [30] | 240 | Yes | No | No | No | No | Yes | No | |||
| Liu & Xing [32] | 129 | Yes | Yes | Yes | Yes | ||||||
| Xing et al. [33] | 507 | Yes | No | No | Yes | Yes | No | No | No | Yes | |
| Wang et al. [34] | 52 FTC | Yes | No | No | Yes | ||||||
| Liu et al. [35] | 430 Chinese | Yes | Yes | Yes | No | Yes | Yes | ||||
| Melo et al. [36] | 469 | Yes | Yes | No | No | No | Yes | Yes | Yes | Yes | Yes |
| Liu et al. [37] | 144 | Yes | No | Yes | Yes | ||||||
| Vinagre et al. [20] | 263 | Yes | Yes | Yes | |||||||
| Liu et al. [21] | 414 | Yes |