Table 4.
Summary of five large studies that reported associations between TERT promoter mutations and clinicopathological features of PTC
| Muzza et al. 2015 [30] | Xing M et al. 2014 [33] | Liu X et al. 2014 [35] | Melo M et al. 2014 [36] | Liu T et al. 2014 [37] | De Biase et al. 2015 [38] | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M (22) | W (160) | P value | M (61) | W (446) | P value | M (42) | W (325) | P value | M (25) | W (307) | P value | M (18) | W (38) | P value | M (19) | W (385) | P value | |
| Age | 57.6 (29–82) | 44.2 (14–80) | 0.004 | 51.7 ± 15.7 | 45.1 ± 13.6 | <0.001 | 53.40 ± 16.14 | 43.66 ± 12.91 | 0.00 | 58.4 ± 13.2 | 43.6 ± 15.3 | <0.001 | 68 (49–84) | 36 (22–97) | <0.0001 | 50.2 ± 11.5 | 47.8 ± 12.8 | 0.39 |
| Size | 2.2 | 1.93 | 0.34 | 2.3 (1.2–3.5) | 1.8 (1.1–3) | 0.048 | 3.14 ± 1.62 | 2.48 ± 1.58 | 0.03 | 3.2 ± 2.2 | 2.3 ± 1.4 | 0.005 | 5.9 ± 2.9 | 6.2 ± 2.5 | 0.68 | |||
| ETE | 11/22 (50) | 85/160 (53.1) | 0.9 | 27/58 (46.5) | 66/439 (15) | <0.001 | 9/32 (28.1) | 17/207 (8.2) | 0.00 | 14/18 (77.8) | 162/250 (64.8)) | 0.26 | ||||||
| Vascular invasion | 14/54 (25.9) | 63/437 (14.1) | 0.028 | 5/16 (31.3) | 98/241 (40.7) | 0.46 | ||||||||||||
| LNM | 11/22 (50) | 83/160 (51.8) | 0.9 | 31/59 (50.8) | 122/438 (27.8) | <0.001 | 7/26 (26.9) | 68/213 (31.9) | 0.60 | 18/23 (6) | 184/275 (66.9) | 0.26 | 4/12 (33.3) | 53/254 (20.8) | 0.29 | |||
| Distant Mets | 12/61 (19.7) | 10/446 (2.2) | <0.001 | 5/18 (27.8) | 31/275 (14.7) | 0.07 | 7/13 (53.8) | 3/38 (7.9) | 0.001 | |||||||||
| Higher TNM III/IV | 10/22 (45.5) | 49/160 (30.6) | 0.09 | 29/61 (47.5) | 77/446 (17.5) | <0.001 | 11/26 (42.31) | 52/213 (24.41) | 0.05 | 10/14 (71.4) | 66/211 (31.3) | 0.02 | 4/15 (26.7) | 61/332 (18.4) | 0.62 | |||
| Recurrence | 10/22 (45) | 29/160 (18) | 0.002 | 29/61 (47.5) | 51/466 (11.4) | <0.001 | 10/16 (62.5) | 48/195 (24.6) | 0.001 | 1/12 (8.3) | 6/276 (2.2) | 0.20 | ||||||
| BRAF V600E | 10/64 (15.6) | 54/160 (33.8) | 0.34 | 35/61 (57.8) | 159/446 (35.750 | 0.007 | 40/46 (86.9) | 210/362 (58) | <0.001 | 18/24 (75) | 130/277 (46.9) | 0.008 | ||||||
| Death | 2/19 (10.5) | 3/256 (1.1) | 0.001 | 11/13 (84.6) | 8/38 (21.1) | <0.0001 | ||||||||||||
ETE extrathyroidal extension/invasion, LNM lymph node metastases, Mets metastases, TNM tumor node metastasis staging system