Table 3.

Multivariable analysis stratified by stage

	All stages (N = 2956)			Early stage (N = 679)			Late stage (N = 2277)
	HR	95 % CI	p value	HR	95 % CI	p value	HR	95 % CI	p value
APM Use
Never	1.00			1.00			1.00
Before diagnosis	0.97	0.81–1.15	0.69	0.87	0.51–1.48	0.61	0.98	0.82–1.18	0.84
After diagnosis	0.36	0.20–0.65	0.0007	0.28	0.08–0.89	0.03	0.41	0.20–0.85	0.02
Before and after diagnosis	0.53	0.41–0.69	<0.0001	0.48	0.22–1.03	0.06	0.54	0.40–0.71	<0.0001
After time	1.39	1.20–1.61	<0.0001	1.29	1.00–1.65	0.05	1.47	1.17–1.85	0.001
Age (10-year increments)	1.25	1.20–1.30	<0.0001	1.51	1.35–1.72	<0.0001	1.21	1.16–1.27	<0.0001
Stage
I	1.00			1.00
II	1.54	1.23–1.93	0.0002	1.62	1.30–2.04	<0.0001
III	3.35	2.90–3.87	<0.0001				1.00
IV	6.98	6.08–8.02	<0.0001				2.01	1.83–2.21	<0.0001
Unknown/missing	3.45	2.78–4.28	<0.0001				1.08	0.89–1.31	0.46
Histology
Non-adeno	1.00			1.00			1.00
Adeno	0.81	0.73–0.89	<0.0001	0.55	0.44–0.0.69	<0.0001	0.88	0.79–0.97	0.01
SCLC	0.97	0.85–1.11	0.63	0.67	0.27–1.62	0.37	0.99	0.86–1.13	0.86
History of prostate ca
Yes	1.00			1.00			1.00
No	1.00	0.85–1.20	0.91	0.76	0.49–1.19	0.24	1.07	0.89–1.28	0.49