. 2016 Jul 1;7(5-6):327–335. doi: 10.1007/s12672-016-0267-0

Table 6.

Features of 21-hydroxylase and 11β-hydroxylase deficiency in patients with adrenocortical carcinoma without hypersecretion of cortisol and its metabolites (ACC) and in patients with adrenocortical carcinoma and Cushing’s syndrome (ACC-CS) by gas chromatography-mass spectrometry

Rations	Median/lower and upper quartiles
	Healthy persons (n = 25)	Hormonally non-active adenomas (n = 52)	Patients with adrenocortical carcinoma
	Healthy persons (n = 25)	Hormonally non-active adenomas (n = 52)	ACC(n = 18)	ACC-CS (n = 13)
(THE + THF + allo-THF)/P3	6/5–8	7/5–11	2.7/1.5–3.6* p = 0.001	4.4/2.1–9.5
(THE + THF + allo-THF)/11-oxo-P3	169/135–219	97/75–114*	23/19–40*	56/18–75*
(THE + THF + allo-THF)/THS	138/47–160	45/27–71*	5.4/2.3–16.1* p = 0.001	16/3–29* p = 0.04

*p < 0.05—comparison with healthy persons; p—comparison with hormonally non-active adenomas