Table 2.

Thyroid cancer SNPs identified through GWAS

Variant (risk allele), chromosome	Gene(s)	Combined OR (95 % CI)	p value	Reference	Replicated in other populations? (references)
rs965513[A], 9q22.33	FOXE1, XPA, C9orf156, HEMGN	1.75 (1.59, 1.94)	1.7 × 10−27	[61]	Yes (60, 62, 64–69)
rs944289[T], 14q13.3a	NKX2-1, BRMS1L, MBIP, SFTA3	1.37 (1.24, 1.52)	2.0 × 10−9	[61]	Yes (60, 62, 64–69)
rs966423[C], 2q35b,c	DIRC3	1.34 (1.22, 1.47)	1.3 × 10−9	[60]	Yes (62, 63, 65)
rs2439302[G], 8p12c	NRG1	1.36 (1.23, 1.50)	2.0 × 10−9	[60]	Yes (60, 65)
rs116909374[T], 14q13.3a	MBIP, NKX2-1	2.09 (1.68, 2.60)	4.6 × 10−11	[60]	No
rs11823005 [C], 11q25	SNX19	1.35 (1.12–1.62)	1.7 × 10−3	[62]	No
rs6759952 [T], 2q35b	DIRC3	1.30 (1.18–1.43)	7.3 × 10−8	[62]	No
rs10238549 [C], 7q21	IMMP2L	1.27 (1.15–1.40)	4.1 × 10−6	[62]	No
rs7800391 [T], 7q21	IMMP2L	1.25 (1.14–1.38)	5.7 × 10−6	[62]	No
rs7617304 [A], 3q25.32c	RRARES1	1.25 (1.12–1.39)	4.6 × 10−5	[62]	No
rs10781500 [C], 9q34.3	SNAPC4	1.23 (1.12–1.36)	3.5 × 10−5	[62]	No
rs2633322 [C], 10q22	PLAU	1.21 (1.06–1.38)	5.3 × 10−3	[62]	No
rs9951245 [G], 18q22	GTSCR1	1.20 (1.09–1.33)	9.8 × 10−4	[62]	No
rs7267944[C] 20q12	DHX35	1.32 (1.20–1,46)	1.34 × 10−8	[63]	No
rs10136427[C] 14q24	BATF	1.30 (1.17–1.44)	9.30 × 10−7	[63]	No
rs1159444 [T], 3p22	GPD1L	1.23 (1.09–1.39)	9.13 × 10−4	[63]	No
rs13184587[G] 5q13-14c	ARSB	1.17 (1.07–1.27)	7.16 × 10−4	[63]	No
rs2245026[G] 13q21-22	DACH1	1.17 (1.06–1.30)	2.09 × 10−3	[63]	No
rs1220597[C] 13q11c	SPATA13	1.16 (1.07–1.25)	2.64 × 10−4	[63]	No
rs2281016[A] 1q23-24	TIPRL	1.16 (1.06–1.27)	2.03 × 10−3	[63]	No

^aThe 14q13.3 SNPs rs966423 and rs116909374 are in separate linkage disequilibrium regions and associations at each SNP remained significant after controlling for the other

^bThe 2q35 SNPs rs966423 and rs6759952 are within the same linkage disequilibrium region and likely represent one association signal

^cIntragenic SNPs