Table 2.
Summary of colorectal lesions found in men and women analyzed with regard to number, histology, morphology, and localization according to serum PTH concentrations
| PTH (ng/ml) | Men (N = 777) | Women (N = 701) | ||||
|---|---|---|---|---|---|---|
| <55 (N = 741) | >55 (N = 36) | P value | <55 (N = 661) | >55 (N = 40) | P value | |
| Number (total adenoma) | ||||||
| >0 | 372 (50.2) | 12 (33.3) | 0.048 | 216 (32.7) | 16 (40.0) | 0.339 |
| 1 | 186 (25.1) | 8 (22.2) | 134 (20.3) | 4 (10.0) | ||
| ≥2 | 186 (25.1) | 4 (11.1) | 0.091* | 82 (12.4) | 12 (30.0) | 0.004* |
| Advanced | 60 (8.1) | 2 (5.6) | 0.582 | 25 (3.8) | 5 (12.5) | 0.008 |
| Advanced proximal colon | 25 (3.4) | 0 (0) | 0.263 | 14 (2.0) | 4 (10.0) | 0.002 |
| Advanced distal colon | 24 (3.2) | 2 (5.6) | 0.450 | 9 (1.4) | 2 (5.0) | 0.072 |
| Advanced rectum | 14 (1.8) | 0 (0) | 0.405 | 3 (0.5) | 1 (2.5) | 0.095 |
| N, histology | ||||||
| >0, tubular | 249 (33.6) | 8 (22.2) | 0.156 | 124 (18.8) | 12 (30.0) | 0.081 |
| 1, tubular | 148 (20.0) | 6 (16.7) | 93 (14.1) | 7 (17.5) | ||
| ≥2, tubular | 101 (13.6) | 2 (5.6) | 0.281* | 31 (4.7) | 5 (12.5) | 0.068* |
| Tubulovillous | 22 (3.0) | 0 (0.0) | 0.165 | 13 (2.0) | 3 (7.5) | 0.023 |
| With any dysplasia | 83 (11.2) | 1 (2.8) | 0.112 | 46 (7.0) | 7 (17.5) | 0.014 |
| Dysplasia proximal colon | 46 (6.2) | 0 (0) | 0.123 | 27 (4.1) | 6 (15.0) | 0.002 |
| Dysplasia distal colon | 34 (4.6) | 1 (2.8) | 0.609 | 18 (2.7) | 5 (12.5) | 0.001 |
| Dysplasia rectum | 22 (3.0) | 0 (0) | 0.294 | 7 (1.1) | 1 (2.5) | 0.405 |
| Morphology of adenoma | ||||||
| Flat | 63 (8.5) | 2 (5.6) | 0.533 | 45 (6.8) | 4 (10.0) | 0.442 |
| Sessile | 334 (45.1) | 10 (27.8) | 0.041 | 175 (26.5) | 15 (37.5) | 0.128 |
| Pedunculated | 48 (6.3) | 1 (2.3) | 0.277 | 17 (2.6) | 4 (8.9) | 0.015 |
| Localization | ||||||
| >0, proximal colon | 191 (25.8) | 5 (13.9) | 0.109 | 119 (18.0) | 8 (20.0) | 0.750 |
| 1, proximal colon | 123 (16.6) | 4 (11.1) | 90 (13.6) | 6 (13.3) | ||
| ≥2, proximal colon | 68 (9.2) | 1 (2.8) | 0.239* | 29 (4.4) | 2 (4.4) | 0.950* |
| >0, distal colon | 176 (23.8) | 6 (16.7) | 0.327 | 91 (13.8) | 13 (32.5) | 0.001 |
| 1, distal colon | 121 (816.3) | 2 (5.6) | 67 (10.1) | 11 (27.5) | ||
| ≥2, distal colon | 55 (7.4) | 4 (11.1) | 0.187* | 24 (3.6) | 2 (5.0) | 0.003* |
| >0, rectum | 150 (20.2) | 3 (8.3) | 0.079 | 65 (9.8) | 6 (15.0) | 0.293 |
| 1, rectum | 113 (15.3) | 3 (8.7) | 53 (8.0) | 4 (10.0) | ||
| ≥2, rectum | 37 (5.0) | 0 (0) | 0.173* | 12 (1.8) | 2 (5.0) | 0.331* |
The figures in the columns refer to the respective number of adenomas detected. Percentage values are in parentheses. In the distal colon, a significantly increased rate of adenomas, particularly those with dysplasia, was found in women with higher PTH concentration. The size of adenomas in the various groups is not presented as there were no differences in either men or women. Advanced adenomas include adenomas with villous features (>25 %), size of 1.0 cm or more, high-grade dysplasia, or early invasive cancer
PTH parathyroid hormone
*P value referring to the comparison for the number of adenomas (coded = 0, 1, or ≥2) (two and more) between high and low PTH; other P values referring to the comparison of presence or absence of the respective adenomas between the defined groups