Table 1.
List of candidate genes whose protein products are associated with methylxanthine receptors, enzymes that metabolize these pharmacologically active agents and certain phosphodiesterase targets
| Gene symbol | Aliases | Gene ID | |
|---|---|---|---|
| Methylxanthine alkaloid receptors | |||
| Adenosine A1 receptor | ADORA1 | RDC7 | 134 |
| Adenosine A2a receptor | ADORA2A | A2aR, ADORA2, RDC8 | 135 |
| Adenosine A2b receptor | ADORA2B | ADORA2 | 136 |
| Adenosine A3 receptor | ADORA3 | A3AR | 140 |
| Dopamine receptor D2 | DRD2 | D2DR, D2R | 1813 |
| Calcium channel, voltage-dependent | CACNA1S | CACNL1A3, CCHL1A3, Cav1.1, HOKPP, HOKPP1, MHS5, TTPP1, hypoPP | 779 |
| Ryanodine receptor 1 (skeletal) | RYR1 | CCO, MHS, MHS1, PPP1R137, RYDR, RYR, RYR-1, SKRR | 6261 |
| Antigen with calponin homology | SPECC1L | CYTSA, GBBB2, OBLFC1 | 23384 |
| Phosphodiesterases | |||
| Phosphodiesterase 1A | PDE1A | CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A | 5136 |
| Phosphodiesterase 1B | PDE1B | HEL-S-79p1, PDES1B, PDE1B | 5153 |
| Phosphodiesterase 1C | PDE1C | Hcam3, cam-PDE 1C, hCam-3 | 5137 |
| Phosphodiesterase 3A | PDE3A | CGI-PDE, CGI-PDE A, CGI-PDE-A, HTNB | 5139 |
| Phosphodiesterase 4A | PDE4A | DPDE2, PDE4, PDE46 | 5141 |
| Phosphodiesterase 4B | PDE4B | DPDE4, PDEIVB | 5142 |
| Phosphodiesterase 5A | PDE5A | CGB-PDE, CN5A, PDE5 | 8654 |
| Metabolizing enzymes | |||
|
Cytochrome P450, family 1, subfamily A, polypeptide 2 |
CYP1A2 | CP12, P3–450, P450(PA) | 1544 |
|
Cytochrome P450, family 2, subfamily A, polypeptide 6 |
CYP2A6 | CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | 1548 |
|
Cytochrome P450, family 3, subfamily A, polypeptide 4 |
CYP3A4 | CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | 1576 |
|
Cytochrome P450, family 2, subfamily C, polypeptide 8 |
CYP2C8 | CPC8, CYPIIC8, MP-12/MP-20 | 1558 |
|
Cytochrome P450, family 2, subfamily C, polypeptide 9 |
CYP2C9 | CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | 1559 |
|
Cytochrome P450, family 2, subfamily E, polypeptide 1 |
CYP2E1 | CPE1, CYP2E, P450-J, P450C2E | 1571 |
|
N-acetyltransferase 2 (arylamine N-acetyltransferase) |
NAT2 | AAC2, NAT-2, PNAT | 10 |
| Xanthine dehydrogenase | XDH | XAN1, XO, XOR | 7498 |