Table 2.
CVD | Heterogeneity test MR‐Egger | Heterogeneity test IVW | Pleiotropy test | ||||||
---|---|---|---|---|---|---|---|---|---|
Q | Q df | Q P value | Q | Q df | Q P value | Egger intercept | SE | P value | |
Heart failure | 12.8 | 10 | 0.236 | 13.6 | 11 | 0.256 | 0.006 | 0.008 | 0.444 |
Coronary artery disease | 3.4 | 10 | 0.969 | 6.0 | 11 | 0.875 | 0.014 | 0.009 | 0.142 |
Atrial fibrillation | 12.7 | 11 | 0.312 | 12.8 | 12 | 0.383 | 0.003 | 0.012 | 0.788 |
Any stroke | 11.7 | 12 | 0.474 | 19.5 | 13 | 0.109 | 0.022 | 0.008 | 0.016 |
Any ischemic stroke | 11.3 | 12 | 0.506 | 18.0 | 13 | 0.158 | 0.022 | 0.009 | 0.024 |
CVD indicates cardiovascular disease; IVW, inverse‐variance weighting; MR, Mendelian randomization; Q, heterogeneity statistic Q; and Q df, Q degree of freedom.