Table 3.

Associations of Genetically Predicted CVD With Risk of Anemia in Sensitivity Analyses in FinnGen Study

CVD	Heterogeneity test MR‐Egger			Heterogeneity test IVW			Pleiotropy test
	Q	Q df	Q P value	Q	Q df	Q P value	Egger intercept	SE	P value
Heart failure	9.2	8	0.327	10.1	9	0.339	−0.017	0.019	0.389
Coronary artery disease	31.4	21	0.067	32.0	22	0.079	−0.006	0.010	0.561
Atrial fibrillation	19.9	19	0.403	22.3	20	0.324	−0.010	0.007	0.143
Any stroke	18.0	6	0.006	18.0	7	0.012	0.011	0.065	0.875
Any stroke*	11.5	5	0.042	11.6	6	0.072	−0.006	0.058	0.920
Any ischemic stroke	23.5	6	0.001	24.0	7	0.001	−0.028	0.086	0.757
Any ischemic stroke†	7.3	4	0.119	8.7	5	0.120	−0.052	0.059	0.431

CVD indicates cardiovascular disease; IVW, inverse‐variance weighting; MR, Mendelian randomization; Q, heterogeneity statistic Q; and Q df, Q degree of freedom.

^*Any stroke, “rs10774624” was removed as an outlier in the MR pleiotropy residual sum and outlier analysis.

^†Any ischemic stroke, “rs2634074” and “rs4942561” were removed as outliers in the MR pleiotropy residual sum and outlier analysis.