Table 1.

Distances for Various Interactions Between Na_V 1.5 Channel and PIP₃

	Mouse			Human
	Residue	AA	Distance, Å	Residue	AA	Distance, Å
Hydrophobic interactions	409	LEU	3.60	409	LEU	3.59
	409	LEU	3.77	409	LEU	3.76
	932	VAL	3.63	930	VAL	3.63
	932	VAL	3.71	930	VAL	3.71
	933	LEU	3.54	931	LEU	3.55
	933	LEU	3.78	931	LEU	3.79
	936	PHE	3.69	934	PHE	3.68
	936	PHE	3.73	934	PHE	3.73
	1420	PHE	3.72	1418	PHE	3.71
	1461	PHE	3.40	1459	PHE	3.39
	1468	ILE	3.57	1466	ILE	3.59
	1468	ILE	3.66	1466	ILE	3.65
	1769	TYR	3.75	1767	TYR	3.77
Hydrogen bonds*	371	GLN	3.41	371	GLN	3.44
	–	–	–	371	GLN	2.87
	–	–	–	401	SER	3.80
	–	–	–	896	CYS	2.77
	1419	THR	2.12	1417	THR	2.12
	–	–	–	1419	LYS	2.64
	1712	SER	3.03	1710	SER	3.05
Salt bridges	1421	LYS	4.38	1419	LYS	4.33
	1421	LYS	4.97	1419	LYS	4.99

AA indicates amino acid; CYS, cysteine; GLN, glutamine; ILE, isoleucine; LEU, leucine; LYS, lysine; PHE, phenylalanine; SER, serine; THR, threonine; TYR, tyrosine; and VAL, valine.

^*For hydrogen bonds, the hydrogen‐acceptor distance is given.