Table 3.
Variant Group by Race Categories
| FH variant group | White (n=58 121) | Black (n=1133) | Other (n=475)* | P value |
|---|---|---|---|---|
| P/LP | 279 (0.5%) | 1 (0.1%) | 0 (0%) | 0.1384 |
| Suspicious VUS | 134 (0.2%) | 7 (0.6%) | 1 (0.2%) | 0.0063 |
| VUS | 1492 (2.6%) | 47 (4.2%) | 16 (3.4%) | <0.0001 |
| LB/B | 2603 (4.5%) | 248 (21.9%) | 24 (5.0%) | <0.0001 |
| No variants | 56 613 (92.2%) | 830 (73.3%) | 434 (91.4%) | … |
The distribution of the variant groups was significantly different between Black and White biobank participants (P<0.0001).
FH indicates familial hypercholesterolemia; LB/B, likely benign or benign; P/LP, pathogenic or likely pathogenic; and VUS, variants of uncertain significance. *Other includes 38% Asian, 24% Unknown, 20% American Indian or Alaska Native, and 18% Native Hawaiian or Other Pacific Islander.