Table 4.
Participants With a P/LP FH Variant: Comparison of Those Identified by Algorithm Versus Those Not Identified
| Variable | Participants with P/LP FH variants identified by either FIND FH or Mayo | P value | |
|---|---|---|---|
| No (N=83) | Yes (N=197) | ||
| FH gene | |||
| APOB | 32 (43.8%) | 64 (38.3%) | 0.4226 |
| LDLR | 41 (56.2%) | 103 (61.7%) | |
| Age, y | |||
| Mean (SD) | 59.4 (13.97) | 57.7 (13.97) | 0.2165 |
| Median (IQR) | 63.0 (50.0–70.0) | 59.0 (47.0–67.0) | |
| Female sex, n (%) | 40 (48.2%) | 120 (60.9%) | 0.0495 |
| Race, n (%) | |||
| Black | 0 (0.0%) | 1 (0.5%) | 0.5155 |
| White | 83 (100.0%) | 196 (99.5%) | |
| Body mass index | |||
| Mean (SD) | 30.1 (8.34) | 31.5 (7.35) | 0.0919 |
| Median (IQR) | 29 (24–34) | 31 (26–35) | |
| Lipid‐lowering therapy, n (%) | 9 (10.8%) | 81 (41.1%) | <0.0001 |
| LDL‐C | |||
| Mean (SD) | 153.7 (26.59) | 277.6 (77.56) | <0.0001 |
| Median (IQR) | 160 (134–174) | 259 (221–313) | |
| HDL‐C | |||
| Mean (SD) | 49.8 (13.40) | 52.4 (15.33) | 0.2472 |
| Median (IQR) | 47 (40–62) | 50 (42–62) | |
| Total cholesterol | |||
| Mean (SD) | 222.6 (32.10) | 319.9 (65.41) | <0.0001 |
| Median (IQR) | 230 (200–249) | 305 (274–350) | |
| Triglycerides | |||
| N (missing) | 75 (8) | 183 (14) | 0.858 |
| Mean (SD) | 120.9 (57.69) | 138.8 (70.65) | |
| Median (IQR) | 103 (77–155) | 119 (86–178) | |
| Systolic blood pressure | |||
| Mean (SD) | 125.1 (17.37) | 123.9 (14.17) | 0.9633 |
| Median (IQR) | 122 (112–134) | 122 (113–132) | |
| Diastolic blood pressure | |||
| Mean (SD) | 72.9 (9.45) | 72.8 (10.17) | 0.8473 |
| Median (IQR) | 74 (64–80) | 72 (66–80) | |
| Family history of heart disease | 9 (10.8%) | 17 (8.6%) | 0.5599 |
| ASCVD, n (%) | 32 (38.6%) | 69 (35.0%) | 0.5744 |
| Diabetes, n (%) | 24 (28.9%) | 48 (24.4%) | 0.4263 |
| CKD, n (%) | 11 (13.3%) | 27 (13.7%) | 0.9196 |
| Smoking status | |||
| Current | 16 (19.3%) | 30 (15.2%) | 0.0919 |
| Former | 20 (24.1%) | 74 (37.6%) | |
| Never | 47 (56.6%) | 93 (47.2%) | |
| Hypothyroidism, n (%) | 11 (13.3%) | 33 (16.8%) | 0.4626 |
ASCVD indicates atherosclerotic cardiovascular disease; CKD, chronic kidney disease; FIND, Flag, Identify, Network, Deliver; FH, familial hypercholesterolemia; HDL‐C, high‐density lipoprotein cholesterol; IQR, interquartile range; LDL‐C, low‐density lipoprotein cholesterol; and P/LP, pathogenic or likely pathogenic.