Table 2.

Association Between Internet Participation and Outcomes (Adherence and Clinical)

Outcome	Cumulative incidence function estimate at median follow‐up		Incidence rate (events per 100 patient years of follow‐up)		Unadjusted		Adjusted*
	Noninternet participant	Internet participant	Noninternet participant	Internet participant	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value
Medication adherence end point: dose switching or aspirin discontinuation	48.84	37.39	37.33 (788)	24.25 (4171)	1.44 (1.34–1.56)	<0.001	1.46 (1.34–1.60)	<0.001
Dose switching	36.51	23.81	27.71 (585)	15.12 (2601)	1.71† (1.57–1.87)	<0.001	1.54† (1.39–1.71)	<0.001
Aspirin discontinuation	16.89	15.46	9.24 (255)	8.67 (1722)	1.06 (0.93–1.21)	0.359	1.25 (1.07–1.45)	0.005
Composite clinical end point: all‐cause death, myocardial infarction, or stroke	13.35	6.49	6.74 (271)	3.14 (888)	2.16 (1.88–2.47)	<0.001	1.67 (1.42–1.97)	<0.001
Myocardial infarction	5.03	2.62	2.36 (96)	1.21 (345)	1.90‡ (1.51–2.38)	<0.001	1.44‡ (1.09–1.92)	0.011
Stroke	2.40	1.08	1.12 (46)	0.52 (148)	2.12‡ (1.53–2.96)	<0.001	1.39‡ (0.92–2.11)	0.117
All‐cause death	7.60	3.58	3.86 (165)	1.74 (507)	2.24 (1.88–2.67)	<0.001	1.90 (1.54–2.35)	<0.001
Safety end point: major bleeding with associated blood product transfusion	0.79	0.59	0.46 (19)	0.27 (78)	1.65‡ (1.00–2.73)	0.049	1.08‡ (0.59–1.97)	0.797

^* Adjusted for age, sex, race, ethnicity, and invitation method.

^† Cause‐specific hazard ratio.

^‡ Subdistribution hazard ratio.