Table 3.

Unadjusted association of clinical characteristics with nephron number in the retained kidney in 3020 living kidney donors and 1354 patients with kidney tumor

Clinical Characteristic	Living Kidney Donors		Patients with Kidney Tumor
	Estimate	P Value	Estimate	P Value
Age, per 10 yr (up to age 70 yr)	−65,680	<0.0001	−88,180	<0.0001
Age, per 10 yr (>70 yr)	−64,971	0.81	−167,039	<0.0001
Male	136,515	<0.0001	129,636	<0.0001
Height, per SD	72,943	<0.0001	94,808	<0.0001
BMI, per SD	12,738	0.13	16,602	0.13
Hypertension	−100,428	<0.0001	−122,611	<0.0001
Diabetes	—	—	−55,181	0.08
Family history of ESKD	−28,713	0.08	—	—
mGFR, per SDb	78,022	<0.0001	—	—
eGFR, per SD	64,169	<0.0001	139,198	<0.0001
24-h urine albumin, per SDc	7638	0.36	—	—
24-h protein >165 mgd	−34,486	0.37	−93,398	<0.0001
Tumor volume per doubling	—	—	5301	0.37

BMI, body mass index, mGFR, measured GFR.

^bMeasured GFR imputed in 520 donors.

^cTwenty-four–hour urine albumin imputed in 600 donors.

^dTwenty-four–hour urine protein imputed in 42 donors and 180 patients with tumor.