Table 4.

Multivariable-adjusted association of clinical characteristics with nephron number in retained kidney in 3020 donors and 1354 patients with tumor

Clinical Characteristic	Living Kidney Donors		Patients with Kidney Tumor		Test for Interaction
	Estimate	P Value	Estimate	P Value
Age per 10 yr (up to age 70 yr)	−44,704	<0.0001	−40,479	0.002	0.68
Age, per 10 yr (>70 yr)	−39,778	0.44	−97,446	0.0002	0.80
Male	61,677	0.007	41,778	0.16	0.43
Height, per SD	50,522	<0.0001	56,637	<0.0001	0.62
BMI, per SD	15,370	0.06	7658	0.75	0.40
Hypertension	−60,992	0.011	−34,292	0.14	0.26
Diabetes	—	—	−48,421	0.10	—
Family history of ESKD	−78,687	<0.0001	—	—	—
eGFR, per SD	38,624	0.001	96,154	<0.0001	<0.0001
24 h protein >165 mg	−27,354	0.46	−53,211	0.009	0.43

BMI, body mass index.

Each characteristic adjusted for each other characteristic, but with separate models for each cohort ×characteristic interaction.