Table 7.

Nephron number of retained kidney as a predictor of short-term follow-up measured GFR <60 or <45 ml/minutes per 1.73 m²

Median Follow-Up of 4.4 mo by Clinical Care (n=1193)	measured GFR <60 (n=387)		measured GFR <45 (n=38)
	OR (95% CI)	P Value	OR (95% CI)	P Value
Unadjusted
Nephron number, per 100,000	0.91 (0.89 to 0.94)	<0.0001	0.84 (0.76 to 0.93)	0.0005
Nephron number <5th percentile	1.54 (1.02 to 2.34)	0.04	0.92 (0.28 to 3.06)	0.90
Nephron number <10th percentile	1.51 (1.08 to 2.12)	0.02	1.99 (0.92 to 4.28)	0.08
% GSG, per SD	1.31 (1.17 to 1.47)	<0.0001	1.59 (1.32 to 1.91)	<0.0001
IFTA, per 5%	4.11 (1.94 to 8.72)	0.0002	1.18 (0.54 to 2.57)	0.67
IFTA foci density, per SD	1.31 (1.17 to 1.46)	<0.0001	1.21 (0.99 to 1.49)	0.07
Adjusted for nephrosclerosis measuresb
Nephron number, per 100,000	0.92 (0.89 to 0.95)	<0.0001	0.87 (0.78 to 0.96)	0.006
Nephron number <5th percentile	1.46 (0.95 to 2.24)	0.08	0.70 (0.20 to 2.50)	0.58
Nephron number <10th percentile	1.45 (1.03 to 2.05)	0.03	1.62 (0.72 to 3.65)	0.24
Further adjusted for glomerular volume
Nephron number, per 100,000	0.89 (0.86 to 0.93)	<0.0001	0.83 (0.75 to 0.93)	0.001
Nephron number <5th percentile	1.56 (0.99 to 2.44)	0.05	0.72 (0.19 to 2.70)	0.63
Nephron number <10th percentile	1.55 (1.07 to 2.23)	0.02	1.75 (0.75 to 4.11)	0.19
Further adjusted for clinical characteristicsc
Nephron number, per 100,000	0.95 (0.91 to 0.99)	0.02	0.89 (0.79 to 1.01)	0.06
Nephron number <5th percentile	1.65 (0.97 to 2.81)	0.07	0.85 (0.23 to 3.12)	0.80
Nephron number <10th percentile	1.51 (0.98 to 2.32)	0.06	2.06 (0.85 to 4.98)	0.11

OR, odds ratio; CI, confidence interval; GSG, globally sclerotic glomerular; IFTA, interstitial fibrosis and tubular atrophy.

^b%GSG, %IFTA and interstitial fibrosis and tubular atrophy foci density.

^cAge, follow-up time, sex, and baseline GFR.