Table 8.

Nephron number of retained kidney as a predictor of short-term follow-up measured GFR <60 or <45 ml/minutes per 1.73 m²

Median Follow-Up of 10.5 yr by Survey (n=673)	estimated GFR <60 (n=228)		estimated GFR <45 (n=32)
	OR (95% CI)	P Value	OR (95% CI)	P Value
Unadjusted
Nephron number, per 100,000	0.92 (0.88 to 0.96)	<0.0001	0.85 (0.76 to 0.95)	0.003
Nephron number <5th percentile	2.49 (1.36 to 4.55)	0.003	5.29 (2.23 to 12.6)	0.0002
Nephron number <10th percentile	2.72 (1.69 to 4.36)	<0.0001	5.06 (2.37 to 10.8)	<0.0001
%GSG, per SD	1.35 (1.16 to 1.58)	0.0001	1.31 (1.01 to 1.70)	0.04
IFTA, per 5%	3.94 (1.47 to 10.6)	0.007	1.79 (1.03 to 3.09)	0.04
IFTA foci density, per SD	1.19 (1.03 to 1.36)	0.01	1.15 (0.90 to 1.47)	0.27
Adjusted for nephrosclerosis measuresb
Nephron number, per 100,000	0.92 (0.89 to 0.97)	0.0004	0.86 (0.77 to 0.96)	0.008
Nephron number <5th percentile	2.38 (1.28 to 4.42)	0.006	4.90 (1.99 to 12.1)	0.0006
Nephron number <10th percentile	2.68 (1.65 to 4.36)	<0.0001	4.91 (2.22 to 10.8)	<0.0001
Further adjusted for glomerular volume
Nephron number, per 100,000	0.91 (0.86 to 0.95)	<0.0001	0.88 (0.78 to 0.99)	0.03
Nephron number <5th percentile	2.55 (1.35 to 4.85)	0.004	4.07 (1.56 to 10.6)	0.004
Nephron number <10th percentile	2.93 (1.77 to 4.87)	<0.0001	4.29 (1.86 to 9.86)	0.0006
Further adjusted for clinical characteristicsc
Nephron number, per 100,000	0.94 (0.89 to 0.99)	0.04	0.92 (0.81 to 1.04)	0.19
Nephron number <5th percentile	2.61 (1.26 to 5.38)	0.009	4.00 (1.44 to 11.1)	0.008
Nephron number <10th percentile	3.37 (1.89 to 5.99)	<0.0001	4.68 (1.92 to 11.4)	0.0007

OR, odds ratio; CI, confidence interval; GSG, globally sclerotic glomerular; IFTA, interstitial fibrosis and tubular atrophy.

^b%GSG, %IFTA and interstitial fibrosis and tubular atrophy foci density.

^cAge, follow-up time, sex, and baseline GFR.