Table 4.
Therapeutic level of tacrolimus before and after implementation of a standardized protocol
| Algorithm | Levels | Days after Stopping Nirmatrelvir/Ritonavir | Therapeutic n (%) |
Subtherapeutic n (%) |
Supratherapeutic n (%) |
|---|---|---|---|---|---|
| Standard algorithm | Baseline | 18/24 (75) | 3/24 (13) | 3/24 (13) | |
| 1 | 2 (2–2) | 10/24 (42) | 10/24 (42) | 4/24 (17) | |
| 2 | 7 (6–8) | 8/24 (33) | 8/24 (33) | 8/24 (33) | |
| 3 | 13 (11–16) | 10/20 (50) | 5/20 (25) | 5/20 (25) | |
| Simplified algorithm | Baseline | 13/20 (65) | 3/20 (15) | 4/20 (20) | |
| 1 | 2 (2–3) | 7/20 (35) | 11/20 (55) | 2/20 (10) | |
| 2 | 11 (10–13) | 12/20 (60) | 4/20 (20) | 4/20 (20) |
Therapeutic range for tacrolimus is between 4 and 6 ng/L.