TABLE 3.
Association of metabolites with all-cause mortality in the Jackson Heart Study
| Metabolite | N | Events | Model 1 |
Model 2 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI: | FDR p | P-interaction | HR | 95% CI | FDR p | P-interaction | |||
| CAR 6:0 | 2441 | 584 | 1.283 | 1.182, 1.393 | 2.51E-8 | 0.708 | 1.178 | 1.079, 1.287 | 0.00267 | 0.774 |
| 3-Hydroxybutyric acid | 2441 | 584 | 1.147 | 1.051, 1.251 | 0.00284 | 0.820 | 1.143 | 1.047, 1.247 | 0.0134 | 0.774 |
| CAR 2:0 | 2441 | 584 | 1.217 | 1.117, 1.326 | 1.82E-5 | 0.820 | 1.132 | 1.037, 1.235 | 0.0155 | 0.774 |
| CAR 12:0 | 2441 | 584 | 1.219 | 1.120, 1.326 | 1.44E-5 | 0.820 | 1.132 | 1.036, 1.236 | 0.0155 | 0.774 |
| Kynurenic acid | 2441 | 584 | 1.235 | 1.138, 1.341 | 2.44E-6 | 0.577 | 1.149 | 1.029, 1.283 | 0.0278 | 0.750 |
| CAR 10:0 | 2441 | 584 | 1.199 | 1.104, 1.302 | 3.10E-5 | 0.708 | 1.109 | 1.016, 1.209 | 0.0334 | 0.774 |
| CAR 8:0 | 2441 | 584 | 1.184 | 1.092, 1.282 | 6.33E-5 | 0.708 | 1.101 | 1.011, 1.198 | 0.0374 | 0.774 |
| Xanthurenic acid | 2441 | 584 | 0.927 | 0.848, 1.013 | 0.102 | 0.577 | 0.910 | 0.836, 0.991 | 0.0374 | 0.750 |
| N-Oleoyl glycine | 2441 | 584 | 1.146 | 1.036, 1.268 | 0.0105 | 0.577 | 1.113 | 1.005, 1.232 | 0.0449 | 0.372 |
| Acetoacetic acid | 2441 | 584 | 1.061 | 0.977, 1.152 | 0.161 | 0.688 | 1.061 | 0.977, 1.152 | 0.162 | 0.750 |
HRs are expressed as per SD increase in log transformed metabolite level. HRs were calculated from Cox proportional hazards regression models. Model 1 covariates included metabolite, diabetes status, age, and sex. Model 2 covariates included metabolite, diabetes status, age, sex, body mass index, estimated glomerular filtration rate, total cholesterol, high density lipoprotein cholesterol, current smoking status, systolic blood pressure, hypertension medication use, and cardiovascular disease history. Interaction effect was tested with the addition of metabolite by diabetes status interaction term to each of the above models. P values were adjusted based on false discovery rate of 0.05. CAR indicates acylcarnitine and number preceding colon indicates length of carbon chain and number following colon indicates number of double bonds.