Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jul 19;619(7970):585–594. doi: 10.1038/s41586-023-05769-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 7 — a-b. Gene Set Enrichment Analyses (GSEA) for genes upregulated or downregulated in adaptive PT (a) and TAL (b) states compared to reference states. c. Dot plot showing averaged marker gene expression values (log scale) and proportion expressed for snCv3 clusters. d. Dot plot showing averaged marker gene expression values (log scale) and proportion expressed for integrated snCv3/scCv3 reference, degenerative and adaptive stromal clusters. e. Violin plots showing aSTR and ECM (matrisome) scores for snCv3 clusters. f. Visium feature plots of normalized counts for select markers mapped to regions shown in Fig. 3e. Scale bar is 100 µm. g. Visium feature plot of normalized counts for a select marker mapped to region shown in (h). Scale bar is 100 µm. h. Histology and predicted cell types for a medullary region of acute tubular necrosis (cellular cast formation within tubular lumens, loss of brush border, loss of nuclei, and epithelial simplification). Pie charts are proportions of predicted transfer scores. Area corresponds to the upper bounded region in Fig. 3b. Scale bar is 100 µm. i. Predicted transfer scores for area shown in (h). Scale bar is 100 µm.