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. 2023 Jul 19;619(7970):585–594. doi: 10.1038/s41586-023-05769-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Maximum-intensity projections of representative biopsies (cortex or medulla) showing classification label examples (insets i–iii). Altered, altered morphology or injury; C-DN, cortical distal nephron; Glom, glomeruli; V, vessels; VB, vascular bundle. Examples of MPO⁺ and CD68⁺ are indicated (i). The symbols * and # indicate CD68⁺ and MPO⁺ cells, respectively, in (i) and insets. Arrowhead indicates T cell in (iii) and inset. Scale bars, 1 mm (biopsy images), 100 μm (i and ii) and 5 μm (insets). b, Community-based clustering on cell composition for around 20,000 randomly chosen neighbourhoods (15 individuals). The red outline indicates neighbourhoods including the medulla. c, The cellular composition of the neighbourhoods identified in b. d, Pairwise analysis of cells within 1.2 million neighbourhoods (15 individuals); colours are as indicated in c. e, Pearson’s coefficients for select interactions, the colour indicates both the value and direction of the correlation. P values were generated using two-sided t-tests.

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