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. 2023 Jul 19;619(7970):595–605. doi: 10.1038/s41586-023-06298-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Diagram of a human embryo in utero at 6 weeks of gestation. Left, the maternal–fetal interface consisting of decidua basalis (purple) with maternal spiral arteries (light pink) and fetal chorionic villi in the intervillous space (bottom right corner). Middle and right, early-stage (6 weeks) unremodelled spiral artery and progression to late-stage (20 weeks) remodelled artery and anchoring fetal villi. b, Cohort parity distribution. c, Cohort age distribution. d, Cohort distribution of body–mass index. e, Cohort ethnicity distribution. f, TMA construction and serial sections for multiomics workflow. Top, antibody panel, MIBI acquisition and spatial proteomics data extraction. Bottom, morphology marker panel and probe diagram, NanoString DSP ROI selection and spatial transcriptomics data extraction. The schematics in f were created using BioRender (https://biorender.com).

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