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. 2023 Jul 19;619(7970):595–605. doi: 10.1038/s41586-023-06298-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a. Scatter of arteries in LDA space colored by manually-assigned stage. Polynomial fit: remodeling trajectory. Inset: matching each artery point a_i to the SAR trajectory by finding the nearest point along trajectory b_i. The continuous SAR score δ was then defined as the distance from origin x₀ to b_i along the trajectory curve. b. Scatter plot of arteries in LDA space colored by δ. c. Violins of artery δs by manual stage d,e. Scatter plots by δ (left) and GA (right) of EVT frequency out of all cells (d), macrophage frequency out of immune cells (e) Red lines, fitted linear regression, regression p-values on top.

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