Table 1.

Synopsis of the Crosstalk between miRNA and lncRNA for angiogenesis

Cancer	Pre-clinical	Mechanism	miRNA	lncRNA	Impact over Hallmark	Therapeutic intervention for tumor regression	Cellular Signalling/ Molecular effectors	Ref.
Glioblastoma	in vivo (human)	Sponging	miRNA-299	TUG1	Induces angiogenesis, Tumor regression	TUG1 knockout inhibited glioma	VEGF-A	[63]
Oral squamous cell	in vitro	Sponging	miR-297	LINC00668	increased cell proliferation via angiogenesis, Tumor regression	LINC00668 knockout inhibited OSC	VEGF-A	[64]
Osteoclastogenesis	in vitro	Sponging	miR-93-5p	AK131850	cellular proliferation	NA	VEGF-A	[65]
Hepatoblastoma	in vivo	Sponging	miRNA-34a-5p	TUG1	invasion, cellular proliferation	TUG1 knockout inhibited HCC	VEGF-A	[66]
Brain microvascular endothelial cells	in vivo	NA	miR-199a	Snhg1	cellular proliferation		VEGF-A; HIF-1a pathway	[67]
Glioma	in vivo	Sponging	miR-29a	H19	cellular proliferation	knockdown of H19 inhibits glioma	VEGF-A	[68]
Breast cancer	in vivo	NA	miR-3120-5P	WTAPP1	invasion, cellular proliferation	WTAPP1 knockdown and overexpression inhibits breast cancer	PI3K/Akt/mTOR	[69, 70]